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Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

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Kimura Disease-A Case Report.

Abhijeet Bhatia¹, Subhadeep Das¹, Anuradha Deka¹

¹Department of ENT, NEIGRIHMS, Shillong, 793018 India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India

|August 28, 2023

Summary

This summary is machine-generated.

Kimura disease, a rare eosinophilic disorder, typically affects young males with swelling and enlarged glands. Management involves surgery, steroids, and sometimes chemotherapy, but recurrence is common.

Keywords:

Angiolymphatic proliferation Eosinophilic microabscess Hypereosinophilia Kimura Disease Raised serum IgE

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Area of Science:

Immunology
Pathology
Radiology

Background:

Kimura disease is an idiopathic, eosinophilic, hyperplastic, and granulomatous condition.
It predominantly affects young males, presenting with subcutaneous swelling, salivary gland enlargement, and lymphadenopathy.

Purpose of the Study:

To provide a comprehensive overview of Kimura disease.
To discuss diagnostic criteria, imaging, and management strategies.
To highlight the challenges in managing recurrence.

Main Methods:

Diagnosis relies on histopathological examination.
Key indicators include elevated serum IgE and hypereosinophilia.
Magnetic Resonance Imaging (MRI) is the preferred radiological investigation.

Main Results:

The disease is characterized by specific histopathological findings.
Biochemical markers like IgE and eosinophil counts are significantly elevated.
MRI provides detailed visualization for diagnosis and monitoring.

Conclusions:

Kimura disease requires a multi-faceted diagnostic approach combining clinical, biochemical, and imaging data.
Treatment strategies encompass surgical excision, corticosteroid therapy, and potentially chemotherapy.
Despite treatment, the disease has a notable tendency for relapse and recurrence, necessitating long-term follow-up.