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Published on: May 10, 2021
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Comparative Survival Function in Patients with Positive Surgical Margins Following Laryngectomy
Yılmaz Özkul1, Ejder Ciğer2, Mustafa Koray Balcı3
1Department of Otolaryngology-Head & Neck Surgery, Izmir Katip Celebi University, İzmir, Turkey.
Summary
Positive surgical margins (PSM) in laryngeal carcinoma significantly increase recurrence and mortality risks. Achieving negative surgical margins (NSM) is crucial for better disease-free survival (DFS) and overall survival (OS).
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Laryngeal carcinoma presents a significant oncological challenge.
- Surgical margins are critical indicators of treatment success.
Purpose of the Study:
- To compare disease-free survival (DFS) and overall survival (OS) in laryngeal carcinoma patients based on surgical margin status.
- To evaluate the prognostic significance of positive surgical margins (PSM) versus negative surgical margins (NSM).
Main Methods:
- Retrospective analysis of 46 laryngeal carcinoma patients.
- Comparison of DFS and OS between patients with PSM (n=16) and NSM (n=30).
- Survival analysis using Long-Rank tests.
Main Results:
- PSM is an independent risk factor for loco-regional recurrence (HR: 1.6, p=0.004) and disease-related mortality (HR: 3.2, p=0.002).
- Patients with NSM demonstrated significantly longer DFS (p=0.001) and OS (p=0.003).
- 2- and 5-year DFS rates were 57% for PSM vs. 96% and 83% for NSM; OS rates were 80% and 34% for PSM vs. 96% for NSM.
Conclusions:
- Positive surgical margins in laryngeal carcinoma are strongly associated with a poor prognosis.
- Achieving negative surgical margins is vital for improving patient survival outcomes.
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