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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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Development of the Limb Synovial Joints01:07

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Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Attention-Deficit/Hyperactivity Disorder01:30

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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
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Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
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Related Experiment Video

Updated: Jul 18, 2025

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

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Hypermobility spectrum disorders: A review.

Matthew B Carroll1

  • 1Rheumatology, Singing River Health System, 3603 Bienville Blvd, Ocean Springs, MS 39564, USA.

Rheumatology and Immunology Research
|August 28, 2023
PubMed
Summary
This summary is machine-generated.

Joint hypermobility (JH) pain is now classified under hypermobility spectrum disorders (HSDs), updating previous terminology. Diagnosis involves JH with secondary musculoskeletal issues, excluding hypermobile Ehlers-Danlos syndrome (hEDS).

Keywords:
benign joint hypermobility syndromegeneralized joint hypermobilityhyper-mobility spectrum disorderhypermobility Ehlers-Danlos syndromejoint hypermobilityjoint hypermobility syndrome

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Area of Science:

  • Rheumatology
  • Genetics
  • Pain Management

Background:

  • Joint hypermobility (JH) diagnosis and management have evolved.
  • Previous terms like benign joint hypermobility syndrome (JHS) are updated.
  • Genetic advances led to revised Ehlers-Danlos syndrome (EDS) classifications.

Purpose of the Study:

  • Explain the nomenclature update from JHS to hypermobility spectrum disorders (HSDs).
  • Detail musculoskeletal and extra-articular manifestations of HSD subtypes.
  • Provide guidance on diagnosing and treating HSDs.

Main Methods:

  • Literature review on joint hypermobility and related disorders.
  • Analysis of updated diagnostic criteria for HSDs.
  • Synthesis of current treatment strategies for HSDs.

Main Results:

  • Hypermobility spectrum disorders (HSDs) encompass JH with secondary musculoskeletal issues, excluding hypermobile Ehlers-Danlos syndrome (hEDS).
  • Extra-articular manifestations are frequent in HSD subtypes.
  • Multidisciplinary management, lifestyle changes, physical therapy, and pharmacologic interventions are key.

Conclusions:

  • The updated nomenclature clarifies the diagnosis of JH-related conditions.
  • Understanding HSD manifestations guides clinical practice.
  • A comprehensive, multidisciplinary approach optimizes HSD management.