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Fibroblast Growth Factor 23 in COVID-19: An Observational Study
Athena Myrou1, Theodoros Aslanidis2, Keli Makedou3
1Department of Internal Medicine, American Hellenic Educational Progressive Association (AHEPA) University Hospital, Thessaloniki, GRC.
Cureus
|August 28, 2023
Summary
Fibroblast growth factor 23 (FGF23) levels in COVID-19 patients showed variations, but no significant correlation was found with common laboratory markers. Further research is needed to establish a reliable link between FGF23 and COVID-19 severity.
Area of Science:
- Endocrinology
- Infectious Diseases
- Biomarker Research
Background:
- Fibroblast growth factor 23 (FGF23) is part of the endocrine FGF family.
- FGF23 is recognized as a potential biomarker and therapeutic target.
- Limited data exists on the interaction between FGF23 and COVID-19.
Purpose of the Study:
- To investigate FGF23 levels in COVID-19 patients.
- To correlate FGF23 levels with inflammatory markers and other laboratory parameters.
Main Methods:
- Prospective observational study involving 81 COVID-19 patients.
- Analysis of serum FGF23 levels.
- Correlation with biochemistry, complete blood count, and coagulation parameters.
Main Results:
- Serum FGF23 levels were similar across sexes and age groups.
- No significant correlation was observed between FGF23 and biochemistry, blood count, or coagulation parameters in the overall cohort.
- Variations in FGF23 levels were noted among different age groups.
Conclusions:
- FGF23 levels may fluctuate in symptomatic COVID-19 infections.
- Larger, well-designed studies are required to confirm reliable correlations between FGF23 and laboratory parameters in COVID-19.
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