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Obesity as a risk factor for multiple myeloma: insight on the role of adipokines
Wenting Tie1,2, Tao Ma3, Zhigang Yi1
1Department of Hematology, Lanzhou University Second Hospital, Lanzhou, China.
Abstract:
Multiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Genetic and environmental factors are contributed to the etiology of MM. Notably, studies have shown that obesity increases the risk of MM and worsens outcomes for MM patients. Adipokines play an important role in mediating the close association between MM and metabolic derangements. In this review, we summarize the epidemiologic studies to show that the risk of MM is increased in obese. Accumulating clinical evidence suggests that adipokines could display a correlation with MM. In vitro and in vivo studies have shown that adipokines are linked to MM, including roles in the biological behavior of MM cells, cancer-associated bone loss, the progression of MM, and drug resistance. Current and potential therapeutic strategies targeted to adipokines are discussed, proposing that adipokines can guide early patient diagnosis and treatment.
Insights
Obesity elevates multiple myeloma (MM) risk and severity, with adipokines mediating this link. Targeting adipokines may offer new diagnostic and therapeutic strategies for MM patients.
Area of Science:
- Hematology
- Oncology
- Metabolic Research
Background:
- Multiple myeloma (MM) is a cancer of plasma cells in the bone marrow.
- Obesity is a risk factor for MM development and poorer patient outcomes.
- Adipokines, signaling molecules from fat tissue, are implicated in MM pathogenesis and metabolic dysfunction.
Purpose of the Study:
- To review epidemiologic evidence linking obesity to MM risk.
- To explore the role of adipokines in MM biology and progression.
- To discuss adipokine-targeted therapies for MM.
Main Methods:
- Systematic review of epidemiologic studies on obesity and MM.
- Analysis of in vitro and in vivo research on adipokine function in MM.
- Discussion of current and emerging therapeutic strategies targeting adipokines.
Main Results:
- Epidemiologic data confirm obesity as a risk factor for MM.
- Adipokines influence MM cell behavior, bone loss, disease progression, and drug resistance.
- Evidence supports a significant correlation between adipokines and MM.
Conclusions:
- Adipokines are key mediators in the obesity-MM relationship.
- Targeting adipokines presents potential for novel MM diagnostics and therapeutics.
- Further research into adipokine pathways can guide personalized MM treatment.
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