Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of Insomnia, Anxiety and Depression on Clinical Outcomes of Frozen Shoulder After Manipulation Under Anesthesia.

Physiotherapy research international : the journal for researchers and clinicians in physical therapy·2026

Same author

Analysis of immune and autophagy-related genes and their regulatory mechanisms in osteoporosis patients post-menopause.

Frontiers in endocrinology·2026

Same author

SORBS2 regulates diastolic function through cytoskeletal networks and calcium handling.

Communications biology·2026

Same author

Automatic identification of anatomical landmarks in three-dimensional computed tomography/cone-beam computed tomography: a scoping review.

Frontiers in dental medicine·2026

Same author

Corrigendum to "Single-cell RNA-seq reveals functionally distinct biomaterial degradation-related macrophage populations" [Biomaterials Oct:277 (2021) 121116].

Biomaterials·2026

Same author

Preoperative Shoulder Stiffness Was Accompanied by Distinct Supraspinatus Tendon Inflammatory Signatures but Not Inferior Long-term Outcomes After Rotator Cuff Repair.

Clinical orthopaedics and related research·2026

Same journal

Multifunctional ultrafast hydrogel for arthroscopic surgery: An enzymatically cross-linked, nanosilicate-reinforced system promotes dual cartilage and subchondral bone regeneration.

Journal of orthopaedic translation·2026

Same journal

Long-term evaluation of plasma electrolytic oxidation (PEO) surface-modified WE43MEO magnesium alloy screws and plates reveals safe and controlled degradation in a 18-month minipig model.

Journal of orthopaedic translation·2026

Same journal

Corrigendum to 'Author's reply to the letter regarding "CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis"' [J Orthop Transl 2026 Mar 26;57:101087].

Journal of orthopaedic translation·2026

Same journal

Semaglutide alleviates osteoarthritis independent of weight loss via GLP-1R-mediated activation of autophagy through AKT/mTOR inhibition.

Journal of orthopaedic translation·2026

Same journal

Therapeutic effect of mitochondrial transfer on bone tissue diseases: treatment strategy of mitochondrial transplantation and delivery technology.

Journal of orthopaedic translation·2026

Same journal

Histone H3K18 lactylation: An exercise-induced epigenetic mechanism that inhibits osteoclast activity and protects against osteoporosis.

Journal of orthopaedic translation·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 18, 2025

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

Published on: March 1, 2024

Animal model for tendinopathy.

Junchao Luo^1,2,3,4,5,6, Zetao Wang^1,2,3,4,5,6, Chenqi Tang^{1,2,3,4,5,6,7}

¹Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.

Journal of Orthopaedic Translation

|August 28, 2023

Summary

This summary is machine-generated.

Choosing the right animal model is crucial for understanding tendinopathy and developing effective treatments. This review guides researchers in selecting appropriate models for studying disease mechanisms and evaluating therapeutic effects.

Keywords:

Animal model Pathogenesis Tendinopathy Tendon Translational research

More Related Videos

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Published on: March 30, 2018

Related Experiment Videos

Last Updated: Jul 18, 2025

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

Published on: March 1, 2024

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Published on: March 30, 2018

Area of Science:

Orthopedics and Sports Medicine
Translational Research
Animal Models in Disease Study

Background:

Tendinopathy, a common motor system disease, causes pain and functional loss.
Current understanding of tendinopathy mechanisms is incomplete, limiting treatment efficacy.
Animal models are vital for tendinopathy research but have limitations due to species differences.

Purpose of the Study:

To review and summarize existing animal models of tendinopathy.
To determine the appropriate use cases for each model in research.
To guide the selection of animal models for studying tendinopathy mechanisms and therapeutic effects.

Main Methods:

Literature review of PubMed database (January 2000 - December 2022).
Search terms included 'tendinopathy', 'tendinitis', 'model', and various animal species.
Models were classified by simulated pathogenesis, and their advantages/disadvantages were discussed.

Main Results:

Naturally occurring, treadmill, subacromial impingement, and metabolic models are ideal for studying tendinopathy pathophysiology.
Models simulating extracellular matrix imbalance, inflammation, oxidative stress, metabolic disorder, traumatism, and mechanical load are suitable for evaluating treatments.
Six main types of tendinopathy pathogenesis are simulated by current animal models.

Conclusions:

Model selection must align with the specific research purpose for optimal translational value.
No single animal model is universally optimal for inducing tendinopathy.
This review provides a guide for selecting and establishing animal models to improve clinical translation.