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Propranolol for the Treatment of Hemangioma in PHACE Syndrome: A Case Report
Tala Beidas1, Yara Jazzar2, Asem Shadid3
1Dermatology, King Saud Medical City, Riyadh, SAU.
Insights
Oral propranolol effectively treated a large facial hemangioma in an infant with PHACE syndrome. This case demonstrates propranolol
Area of Science:
- Pediatric Medicine
- Dermatology
- Genetics
Background:
- Oral propranolol is a standard treatment for infantile hemangioma.
- PHACE syndrome, a complex condition, includes hemangioma and raises stroke risk concerns with propranolol use.
Abstract:
Oral propranolol is commonly used as a first-line treatment for infantile hemangioma. However, its use in PHACE (posterior fossa anomalies, hemangioma, arterial anomalies, cardiac anomalies, and eye anomalies) syndrome raises concerns that it might exacerbate the patient's risk of stroke. Here, we report the case of a four-month-old premature girl with PHACE syndrome, who presented with a large hemangioma involving the left side of her face, following the V1+V2+V3 distribution, including the upper lip, left ear, and left eye. This condition was successfully treated with propranolol, and no adverse side effects were reported.
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