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Factors Associated with Reaching Mid-Parental Height in Patients Diagnosed with Inflammatory Bowel Disease in
So Yoon Choi1, Sujin Choi2,3, Byung-Ho Choe2,3
1Department of Pediatrics, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.
Insights
Pediatric inflammatory bowel disease patients who have a lower height Z-score at diagnosis and mid-parental height (MPH) Z-score are less likely to reach their MPH. Early intervention is crucial for improving growth outcomes in these children.
Area of Science:
- Pediatric Gastroenterology
- Growth and Development
- Inflammatory Bowel Disease (IBD)
Background:
- Normal growth in children is an intermediate target for Crohn's disease and ulcerative colitis management.
- Investigating factors influencing growth is crucial for optimizing IBD care in pediatric populations.
Purpose of the Study:
- To identify factors associated with achieving mid-parental height (MPH) in pediatric patients with inflammatory bowel disease (IBD).
Main Methods:
- A multicenter retrospective observational study of pediatric IBD patients who reached adult height.
- Logistic regression analyses were used to investigate factors associated with reaching MPH.
Main Results:
- 54.2% of 166 pediatric IBD patients reached their MPH.
- Height Z-score at diagnosis and MPH Z-score were independently associated with reaching MPH.
- A "height Z-score at diagnosis minus MPH Z-score" cutoff of -0.01 effectively predicted reaching MPH.
Conclusions:
- Height Z-score at diagnosis and MPH Z-score are key predictors of growth attainment in pediatric IBD.
- Pediatric IBD patients with a negative "height Z-score at diagnosis minus MPH Z-score" require growth restoration efforts.
Background/Aims:
The recent update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease initiative has added normal growth in children as an intermediate target in Crohn's disease and ulcerative colitis. We aimed to investigate factors associated with reaching mid-parental height (MPH) in patients diagnosed with inflammatory bowel disease in childhood and the adolescent period.
Methods:
This multicenter retrospective observational study included pediatric patients with inflammatory bowel disease that had reached adult height. Factors associated with reaching MPH were investigated by logistic regression analyses.
Results:
A total of 166 patients were included in this study (128 Crohn's disease and 38 ulcerative colitis). Among them, 54.2% (90/166) had reached their MPH. Multivariable logistic regression analysis revealed that height Z-score at diagnosis and MPH Z-score were independently associated with reaching MPH (odds ratio [OR], 8.45; 95% confidence interval [CI], 4.44 to 17.90; p<0.001 and OR, 0.11; 95% CI, 0.04 to 0.24; p<0.001, respectively). According to the receiver operating characteristic curve analysis, the optimal cutoff level of "height Z-score at diagnosis minus MPH Z-score" that was associated with reaching MPH was -0.01 with an area under the curve of 0.889 (95% CI [0.835 to 0.944], sensitivity 88.9%, specificity 84.2%, positive predictive value 87.0%, negative predictive value 86.5%, p<0.001).
Conclusions:
Height Z-score at diagnosis and MPH Z-score were the only factors associated with reaching MPH. Efforts should be made to restore growth in pediatric patients who present with a negative "height Z-score at diagnosis minus MPH Z-score."
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