[Immunomorphological aspects of post-traumatic subatrophy of the eyeball]
I A Filatova1, I M Mokhammad1, S A Shemetov1
1Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia.
Purpose:
The study attempts to characterize immunomorphological disorders at different degrees of post-traumatic subatrophy of the eyeball.
Material And Methods:
The study included 123 patients with blind and unpromising eyes, eyeball subatrophy of various degrees, who were divided into three groups (1, 2 and 3) depending on the degree of eyeball subatrophy.
Results:
The greatest risk of autoimmune inflammation was observed in patients with degree I subatrophy. Contusion injury of the eye was proven to not exclude the course of post-traumatic autoimmune uveitis. The development of post-traumatic subatrophic process is associated with activation of systemic organ-specific immunity, shift of balance in main regulatory subpopulations.
Conclusion:
The study showed that the most severe clinical course of chronic post-traumatic uveitis is observed in patients as a result of penetrating trauma to the eyeball. The contusion nature of such ocular injury does not exclude the development of autoimmune inflammation.
More Related Videos
08:21Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
Published on: October 2, 2018
05:15Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry
Published on: October 20, 2019
