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Related Experiment Videos

Spinal Wada test.

J L Doppman, M Girton, E H Oldfield

    Radiology
    |November 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Intra-arterial injections of pentobarbital and lidocaine in monkeys caused temporary spinal cord dysfunction. These drug effects were reversible and dose-dependent, offering potential for predicting cord blood supply.

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    Area of Science:

    • Neurology
    • Pharmacology
    • Vascular Surgery

    Background:

    • Assessing spinal cord blood supply is critical for procedures like arteriography and embolization.
    • Current methods may have limitations in sensitivity for predicting cord perfusion.

    Purpose of the Study:

    • To evaluate the effects of intra-arterial pentobarbital and lidocaine on spinal cord function in a primate model.
    • To determine the potential of these agents as indicators of cord blood supply.

    Main Methods:

    • Selective intra-arterial injections of varying doses of pentobarbital and lidocaine were administered.
    • The artery of Adamkiewicz and anterior spinal artery of 11 monkeys were targeted.
    • Neurological function and duration of effects were monitored.

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    Main Results:

    • Pentobarbital induced acute paraplegia, while lidocaine caused transient paraplegia with subsequent hyper-reflexia and fasciculations.
    • Effects ranged from 5 to 60 minutes and were dose-dependent.
    • All observed effects were fully reversible.

    Conclusions:

    • Intra-arterial pentobarbital and lidocaine reliably induce reversible spinal cord dysfunction in monkeys.
    • These agents may serve as more sensitive predictors of cord blood supply than angiography.
    • This technique could enhance safety during spinal arteriography and embolization procedures.