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Induction and Validation of Cellular Senescence in Primary Human Cells
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[Skin aging-cellular senescence : What is the future?]

Karin Scharffetter-Kochanek1,2,3, Yongfang Wang4,5, Evgenia Makrantonaki5,6

  • 1Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland. karin.scharffetter-kochanek@uniklinik-ulm.de.

Dermatologie (Heidelberg, Germany)
|August 28, 2023
PubMed
Abstract

Insights

Cellular senescence drives skin aging and related diseases. Therapies like senolytics and senomorphics can deplete senescent cells, promoting skin rejuvenation and organ function.

Area of Science:

  • Gerontology and Regenerative Medicine
  • Cellular Biology
  • Dermatology

Context:

  • Cellular senescence is a primary driver of skin and organ aging.
  • Aging impairs the immune system's ability to clear senescent cells.
  • Senescence is linked to numerous age-related diseases.

Purpose:

  • To review senolytics, senomorphics, and cell-based therapies for skin aging.
  • To explore their mechanisms and clinical potential.
  • To assess their role in reducing cellular senescence.

Summary:

  • Mitochondrial dysfunction and pro-aging pathways activate cellular senescence.
  • This leads to dermal connective tissue degradation and suppressed skin stem cell niches.
  • Senolytics and senomorphics aim to clear senescent cells.

Impact:

  • Depleting senescent cells rejuvenates skin and organ function.
  • Approved senolytics and senomorphics are available.
  • These therapies offer potential for mitigating aging effects.
Keywords:
Organ agingRejuvenationSenolyticsSenomorphicsSkin aging

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