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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Induction and Validation of Cellular Senescence in Primary Human Cells
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[Skin aging-cellular senescence : What is the future?]

Karin Scharffetter-Kochanek1,2,3, Yongfang Wang4,5, Evgenia Makrantonaki5,6

  • 1Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland. karin.scharffetter-kochanek@uniklinik-ulm.de.

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Summary

Cellular senescence drives skin aging and related diseases. Therapies like senolytics and senomorphics can deplete senescent cells, promoting skin rejuvenation and organ function.

Keywords:
Organ agingRejuvenationSenolyticsSenomorphicsSkin aging

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Area of Science:

  • Gerontology and Regenerative Medicine
  • Cellular Biology
  • Dermatology

Context:

  • Cellular senescence is a primary driver of skin and organ aging.
  • Aging impairs the immune system's ability to clear senescent cells.
  • Senescence is linked to numerous age-related diseases.

Purpose:

  • To review senolytics, senomorphics, and cell-based therapies for skin aging.
  • To explore their mechanisms and clinical potential.
  • To assess their role in reducing cellular senescence.

Summary:

  • Mitochondrial dysfunction and pro-aging pathways activate cellular senescence.
  • This leads to dermal connective tissue degradation and suppressed skin stem cell niches.
  • Senolytics and senomorphics aim to clear senescent cells.

Impact:

  • Depleting senescent cells rejuvenates skin and organ function.
  • Approved senolytics and senomorphics are available.
  • These therapies offer potential for mitigating aging effects.