Vitamins in neuropathy: pathophysiological and therapeutic roles

Area of Science:

• Neurology
• Nutritional Science
• Biochemistry

Background:

• Peripheral neuropathy is linked to complex diseases, with vitamin deficiencies being a key risk factor.
• Deficiencies in multiple vitamins are associated with conditions like diabetic neuropathy.
• Vitamin deficiencies manifest in various severe conditions, including chemotherapy-induced neuropathy and carpal tunnel syndrome.

Approach:

• This review synthesizes current literature on the pathophysiological and therapeutic roles of vitamins in peripheral neuropathy.
• The review highlights the clinical manifestations and implications of vitamin deficiencies in neurological disorders.
• It emphasizes the need for further research into vitamin supplementation as a therapeutic strategy.

Key Points:

• Vitamins are crucial for physiological functions; deficiencies can precipitate peripheral neuropathy.
• Vitamin supplementation is a potential therapeutic approach for various neuropathies.
• Evidence suggests a strong link between vitamin deficiencies and diabetic neuropathy.

Conclusions:

• Understanding the therapeutic benefits and mechanisms of vitamin treatment is essential.
• Further clinical trials are required to define optimal vitamin supplementation protocols for different neuropathies.
• Screening for vitamin deficiencies can aid in early diagnosis and timely intervention for patients with peripheral neuropathy.