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Updated: Jul 17, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Toxic neuropathies
Alexander M Rossor1, Hadi Manji
1Queen Square Centre for Neuromuscular Diseases, National Hospital for Neurology, London, UK.
Neuropathic complications from immunotherapy, nitrous oxide, and ciguatera toxin exposure are increasing. Early recognition and symptomatic treatment are crucial, with further research needed for effective therapies.
Area of Science:
- Neurology
- Toxicology
- Immunology
Background:
- Immunotherapy and linezolid have expanded therapeutic uses, while recreational nitrous oxide use is a growing global concern.
- Drug-resistant tuberculosis (TB) and increasing toxin exposure due to global warming present significant public health challenges.
- Neuropathy is a major morbidity associated with these conditions, necessitating focused clinical attention.
Conclusions:
- Neuropathy associated with immunotherapy, nitrous oxide, and ciguatera requires early recognition and symptomatic management.
- Nitrous oxide toxicity should be considered in patients presenting with neuropathy, especially younger individuals.
- Ciguatera toxicity is under-recognized and its prevalence is expected to rise with global warming, necessitating further research into acute and chronic effects.
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