Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of Degradation and Mechanics of Electrospun PCL Fibers through Molecular Weight and PEO Blending.

ACS macro letters·2026
Same author

Epicardial extracellular vesicles modulate gene expression following ischemia-reperfusion injury in heart-on-a-chip.

Materials today. Bio·2026
Same author

γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response.

Nature communications·2026
Same author

Mapping the miRNA landscape of primitive macrophage extracellular vesicles highlights their pro-vasculogenic effects in engineered human cardiac tissue.

APL bioengineering·2026
Same author

Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components.

Nature communications·2026
Same author

Tissue Injury and Biomaterial Treatment Modulate Tumor Growth and Response to Immunotherapy.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jul 17, 2025

Elastomeric PGS Scaffolds in Arterial Tissue Engineering
08:35

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

15.6K

Elastomeric Polyesters in Cardiovascular Tissue Engineering and Organs-on-a-Chip.

Sargol Okhovatian1,2, Amid Shakeri1,2, Locke Davenport Huyer3,4,5

  • 1Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

Biomacromolecules
|August 28, 2023
PubMed
Summary
This summary is machine-generated.

New elastic polyesters offer biocompatible solutions for cardiovascular tissue engineering. These materials enhance tissue integration and reduce inflammation, paving the way for improved cardiac scaffolds and regenerative medicine applications.

More Related Videos

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.0K
A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

5.6K

Related Experiment Videos

Last Updated: Jul 17, 2025

Elastomeric PGS Scaffolds in Arterial Tissue Engineering
08:35

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

15.6K
Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.0K
A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

5.6K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cardiovascular Engineering

Background:

  • Cardiovascular tissue engineering demands elastic, durable materials that mimic native tissue mechanics.
  • Polyester synthesis offers diverse routes to create advanced biomaterials.
  • Biocompatible, elastic, and immunomodulatory polymers are crucial for cardiac constructs.

Purpose of the Study:

  • To review the chemistry and design of polyester elastomers for cardiac tissue scaffolds.
  • To explore the advantages of these materials, including tunable elasticity and biodegradation.
  • To discuss fabrication methods and applications in cardiovascular devices.

Main Methods:

  • Review of polyester synthesis and material design strategies.
  • Analysis of fabrication techniques like electrospinning, 3D printing, and micromolding.
  • Examination of applications in organ-on-a-chip devices and cardiac patches.

Main Results:

  • Polyester elastomers provide biomechanical synergy with native tissues.
  • These materials can reduce *in vivo* inflammatory responses and support *in vitro* tissue maturation.
  • Tunable elasticity, biodegradation, and bioactive compound incorporation are key advantages.

Conclusions:

  • Soft polyesters are promising for cardiovascular tissue engineering.
  • Further research is needed to address challenges for clinical translation.
  • Optimized polyester elastomers can advance cardiac regenerative medicine.