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Restless Legs Syndrome and fatigue in multiple sclerosis: A cross-sectional clinical study
Alessia Pascazio1, Michelangelo Maestri1, Livia Pasquali1
1Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, via Roma 67, Pisa 56126, Italy.
Multiple Sclerosis and Related Disorders
|August 28, 2023
Summary
Restless Legs Syndrome (RLS) affects nearly half of relapsing-remitting multiple sclerosis patients, significantly worsening sleep quality and fatigue. RLS is strongly linked to MS-related disability and mood disorders.
Area of Science:
- Neurology
- Sleep Medicine
- Clinical Research
Background:
- Restless Legs Syndrome (RLS) is a sensorimotor disorder with increased prevalence in Multiple Sclerosis (MS) patients.
- Understanding RLS in relapsing-remitting MS (RRMS) is crucial due to potential impacts on patient well-being.
Purpose of the Study:
- To determine the prevalence of RLS in a cohort of RRMS patients.
- To investigate associations between RLS and MS-related disability, sleep quality, mood disorders, and fatigue.
Main Methods:
- A retrospective, observational study involving 92 RRMS patients.
- Data collection included MS clinical and radiological variables.
- Standardized questionnaires assessed sleep, fatigue, and mood; RLS occurrence was evaluated by sleep disorder specialists.
Main Results:
- RLS prevalence was 47.8% in the RRMS sample.
- Patients with RLS reported significantly worse sleep quality and higher fatigue levels compared to non-RLS patients.
- Fatigue correlated significantly with MS-related disability, poor sleep quality, and mood disorders.
Conclusions:
- The study confirms a high prevalence of RLS in MS patients.
- RLS significantly impacts fatigue and sleep quality in RRMS.
- Findings underscore the importance of screening for RLS in MS management.
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