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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Diffuse large B cell lymphoma presenting as multiple cavitary lung lesions.

Manisha Uppal1, Ahmad Hassan2, Jalil Ahari2

  • 1The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA muppal@mfa.gwu.edu.

BMJ Case Reports
|August 28, 2023
PubMed
Summary
This summary is machine-generated.

This case report details a rare presentation of diffuse large B cell lymphoma (DLBCL) manifesting as cavitary lung lesions. Prompt diagnosis and treatment are crucial for this aggressive lymphoma.

Keywords:
HematologyLung cancer (oncology)Respiratory medicine

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Area of Science:

  • Oncology
  • Pulmonology
  • Hematology

Background:

  • Diffuse large B cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
  • Lung involvement in DLBCL can present with diverse radiological findings.

Observation:

  • A middle-aged female presented with symptoms suggestive of a respiratory infection, including shortness of breath and productive cough.
  • Imaging revealed multiple bilateral cavitary lung masses and nodules, prompting further investigation.
  • Histopathology confirmed the non-germinal center B cell subtype of DLBCL.

Findings:

  • The patient's symptoms improved significantly after initiating a standard chemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone).
  • Elevated lactate dehydrogenase was noted, a common finding in lymphoma.

Implications:

  • This case underscores the importance of considering DLBCL in the differential diagnosis of cavitary lung lesions, especially when initial workups are inconclusive.
  • Early recognition and treatment of pulmonary DLBCL are critical due to its aggressive nature and potential for rapid progression.