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Updated: Jul 17, 2025
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Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
Published on: December 6, 2016
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A neuropathologic feature of brain aging: multi-lumen vascular profiles
Eseosa T Ighodaro1,2, Ryan K Shahidehpour2,3,4, Adam D Bachstetter2,3,4
1Department of Neurology, Emory University, Atlanta, GA, USA.
Acta Neuropathologica Communications
|August 28, 2023
Summary
Multi-lumen vascular profiles (MVPs) are an age-related brain pathology. Increased MVP density in the frontal neocortex correlates with age at death, but risk factors remain unclear.
Area of Science:
- Neuropathology
- Cerebrovascular Disease
- Aging Brain Research
Background:
- Aged brains exhibit various cerebrovascular pathologies beyond infarctions.
- Multi-lumen vascular profiles (MVPs), characterized by multiple lumens within a single vascular channel, are poorly understood.
- Information on MVP prevalence, risk factors, and co-pathologies is limited.
Purpose of the Study:
- To investigate the prevalence, risk factors, and neuropathological associations of MVPs in aging brains.
- To establish correlations between MVP density and demographic, clinical, and neuropathological variables.
- To visualize MVPs in three dimensions using advanced imaging techniques.
Main Methods:
- Analysis of brain samples from the University of Kentucky Alzheimer's Disease Research Center and Pathology Departments, and the University of Pittsburgh Pathology Department.
- Statistical correlation of age at death with MVP density in Brodmann Area 9.
- Exploratory analyses of associations with vascular risk factors, cardiovascular diseases, cerebrovascular diseases, neuropathological variables, and genetic factors (APOE).
- Application of the SeeDB tissue clearing method for 3D imaging of MVPs.
Main Results:
- MVP density in the frontal neocortex (Brodmann Area 9) significantly correlates with age at death (r=0.51, p<0.0001).
- A history of brain trauma showed a nominal association with MVP density (PR=2.1, 95% CI 1.1-3.9) before multiple comparison correction.
- No significant associations were found between MVP density and conventional vascular risk factors, cardiovascular diseases, cerebrovascular diseases, brain arteriolosclerosis, or APOE genotype.
- 3D imaging provided detailed visualization of MVP structures.
Conclusions:
- MVPs represent an age-related cerebrovascular pathology.
- Age is a significant factor associated with increased MVP density.
- Further research is needed to elucidate the clinical-pathological correlations and specific risk factors for MVPs.
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