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NIR light, pH, and redox-triple responsive nanogels for controlled release.

Shuo Chen1, Shuai Yuan1, Qing Bian2

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This study introduces novel spiropyran-based nanogels for controlled drug release. These multi-stimulus responsive nanocarriers offer efficient and tunable drug delivery for complex biological applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Stimulus-responsive nanocarriers are crucial for targeted and controlled drug delivery.
  • Existing nanocarriers often lack the adaptability required for complex biological environments.
  • Organic-inorganic composite nanogels offer potential for enhanced functionality and tunable properties.

Purpose of the Study:

  • To develop a novel spiropyran-based organic-inorganic composite nanogel (NG).
  • To evaluate the drug loading and controlled release capabilities of the nanogel.
  • To demonstrate the multi-stimulus responsiveness for tunable drug release.

Main Methods:

  • Emulsion polymerization using upconverting nanoparticles, spiropyran, acrylic acid, and N,N'-bis(acryloyl)cystamine (BAC).
  • Drug loading studies using doxorubicin hydrochlorides as a model drug.
  • Controlled release experiments under various stimuli: near-infrared (NIR) light, acidic pH, and reducing agents.

Main Results:

  • The composite nanogels exhibited efficient drug loading performance.
  • Controlled drug release was achieved over 24 hours under NIR irradiation, acidic conditions, or reducing agents.
  • Synergistic effect of triple stimulation (NIR, pH 6, reducing agent) enhanced drug release efficiency.

Conclusions:

  • The developed organic-inorganic composite nanogels are highly efficient and controllable drug delivery systems.
  • These nanocarriers offer tunable release profiles, adaptable to complex biological conditions.
  • The novel nanogel platform provides versatile options for advanced stimulus-responsive nanocarriers.