Related Experiment Video
Updated: Jul 17, 2025
06:07
Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
Published on: June 23, 2023
1.6K
Homocysteine and Parkinson's disease
1Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
CNS Neuroscience & Therapeutics
|August 29, 2023
Summary
High homocysteine (Hcy) levels, known as hyperhomocysteinemia, are linked to Parkinson's disease development. This review explores homocysteine's role in Parkinson's pathogenesis and its detrimental effects.
Area of Science:
- Biochemistry
- Neuroscience
- Metabolic pathways
Background:
- Homocysteine (Hcy) is a key metabolite in methionine metabolism.
- Abnormal homocysteine metabolism leads to its accumulation, causing hyperhomocysteinemia.
- Emerging evidence links hyperhomocysteinemia to Parkinson's disease (PD) occurrence and progression.
Purpose of the Study:
- To review the role of homocysteine in the pathogenesis of Parkinson's disease.
- To elucidate the detrimental effects of hyperhomocysteinemia on Parkinson's disease.
Main Methods:
- Literature review of studies on homocysteine and Parkinson's disease.
- Analysis of biochemical pathways and their relation to neurodegeneration.
- Synthesis of current research on hyperhomocysteinemia's impact on PD.
Main Results:
- Homocysteine accumulation is implicated in the neurodegenerative processes of Parkinson's disease.
- Hyperhomocysteinemia exacerbates the pathological features associated with Parkinson's disease.
- Specific mechanisms linking Hcy to PD pathogenesis are discussed.
Conclusions:
- Homocysteine metabolism is a critical factor in Parkinson's disease.
- Hyperhomocysteinemia represents a significant risk factor and contributor to Parkinson's disease progression.
- Further research into Hcy-lowering strategies for PD management is warranted.
Related Concept Videos
01:24Parkinson's Disease: Treatment
295
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
295
01:15Parkinson's Disease: Overview
593
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
593
01:22Lysosomal Hydrolases
3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
740
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
740
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
119
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
119
01:37Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K