Related Experiment Video

Updated: Jul 17, 2025

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

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Caveolin-1 promotes glioma progression and maintains its mitochondrial inhibition resistance

Yu'e Liu1, Yi Chen2, Fei Wang3

  • 1Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.

Discover Oncology
|August 29, 2023
PubMed
Abstract

Insights

Caveolin 1 (CAV1) is highly expressed in aggressive gliomas, promoting tumor growth, metastasis, and resistance to therapy. Targeting CAV1 offers a promising therapeutic strategy for this lethal brain cancer.

Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Molecular Medicine

Background:

  • Glioma is a fatal brain cancer with limited therapeutic options due to challenges like heterogeneity and an immunosuppressive microenvironment.
  • Identifying novel therapeutic targets and understanding glioma pathogenesis are critical for improving patient outcomes.
  • Prognostic biomarkers are essential for guiding treatment strategies in glioma patients.

Purpose of the Study:

  • To investigate the role of scaffolding protein caveolin 1 (CAV1) in glioma progression and its potential as a therapeutic target.
  • To analyze the correlation between CAV1 expression and glioma characteristics, including resistance to oxidative phosphorylation inhibitors.

Main Methods:

  • RNA-sequencing of oxidative phosphorylation (OXPHOS)-inhibition sensitive and resistant glioma cell lines.
  • Comprehensive analysis of RNA sequencing, Whole Genome Bisulfite Sequencing (WGBS) data, and public databases.
  • Correlation analysis of CAV1 expression with pathological processes, immune infiltration, metastasis, stemness, and patient survival.

Main Results:

  • CAV1 is highly expressed in OXPHOS-resistant glioma cells and gliomas, with higher expression correlating with poorer overall survival.
  • CAV1 expression is linked to immune infiltration, tumor metastasis, and glioma stemness.
  • Lower CAV1 promoter methylation was observed in higher-stage gliomas, and high CAV1 expression conferred resistance to OXPHOS inhibitors.

Conclusions:

  • Caveolin 1 (CAV1) is identified as a key gene in glioma progression, influencing multiple pathological processes.
  • CAV1 promotes glioma aggressiveness, metastasis, and therapeutic resistance.
  • CAV1 represents a potential therapeutic target for improving glioma treatment outcomes.
Keywords:
CAV1DNA methylationDrug resistanceGliomaImmunotherapy

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