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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Related Experiment Video

Updated: Jul 17, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Osteoporosis management in primary care.

Lynda Jarrell1

  • 1Lynda Jarrell is a clinical assistant professor at University of Texas at Arlington in Fort Worth, Tex.

The Nurse Practitioner
|August 29, 2023
PubMed
Summary

Osteoporosis management is crucial for fracture prevention, yet it remains underdiagnosed and undertreated despite available medications. Primary care providers play a key role in addressing this prevalent bone disease.

Area of Science:

  • Endocrinology
  • Geriatrics
  • Public Health

Background:

  • Osteoporosis is a widespread bone disease in the US.
  • Effective fracture prevention and management require ongoing care.
  • Primary care providers are essential for managing osteoporosis and preventing fractures.

Purpose of the Study:

  • To review common osteoporosis medications.
  • To highlight the importance of primary care in osteoporosis management.
  • To discuss challenges in diagnosis and treatment.

Main Methods:

  • Review of commonly prescribed osteoporosis medications.
  • Discussion of the role of primary care providers.
  • Analysis of underdiagnosis and undertreatment issues.

More Related Videos

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
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Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

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Related Experiment Videos

Last Updated: Jul 17, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

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Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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Main Results:

  • Various drug classes are available for osteoporosis treatment.
  • Osteoporosis is frequently underdiagnosed and undertreated.
  • Primary care involvement is critical for effective management.

Conclusions:

  • Effective osteoporosis management is achievable with available treatments.
  • Increased primary care provider engagement can improve patient outcomes.
  • Addressing underdiagnosis and undertreatment is vital for public health.