Related Experiment Video
Updated: Jul 17, 2025
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Potential Predictors of Severe and Recurrent Pancreatitis in Children: A Single-Center Experience
1From the Department of Pediatrics, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea.
Insights
C-reactive protein aids early detection of severe pediatric pancreatitis. Obesity is a significant risk factor for pancreatitis recurrence in children, necessitating further investigation.
Area of Science:
- Pediatric Gastroenterology
- Clinical Medicine
- Biomarker Research
Background:
- Severe acute pancreatitis in children necessitates intensive care, underscoring the need for early detection and risk stratification.
- Identifying predictors of pancreatitis severity and recurrence is crucial for optimizing pediatric patient management.
Purpose of the Study:
- To identify early predictors of severe acute pancreatitis in pediatric patients.
- To determine the prevalence of pancreatitis recurrence and associated risk factors in children.
Main Methods:
- Retrospective analysis of medical records for pediatric patients (<18 years) diagnosed with acute pancreatitis between January 2017 and June 2022.
- Classification of pancreatitis severity based on the revised Atlanta criteria.
- Evaluation of C-reactive protein levels and patient demographics as potential predictors.
Main Results:
- Severe pancreatitis occurred in 15.6% of 64 pediatric patients. Younger age and higher C-reactive protein levels were associated with severe pancreatitis.
- C-reactive protein levels at 48 hours post-diagnosis showed a high predictive value (AUC 0.873) for severity.
- Recurrent pancreatitis affected 21.9% of patients, with older age, male sex, and obesity being significant risk factors.
Conclusions:
- C-reactive protein is a feasible biomarker for early risk assessment in pediatric acute pancreatitis.
- Obesity is a notable risk factor for recurrent pancreatitis in children, warranting clinical attention.
Objectives:
Severe pancreatitis often requires intensive care; therefore, early detection is important. This study aimed to evaluate the possible predictors of pancreatitis severity in children. Furthermore, we evaluated the prevalence of pancreatitis recurrence and related factors.
Methods:
We retrospectively analyzed the medical records of patients aged younger than 18 years who were diagnosed with acute pancreatitis between January 2017 and June 2022. Acute pancreatitis was diagnosed and classified based on the revised Atlanta criteria.
Results:
A total of 64 patients were enrolled, and severe pancreatitis was observed in 10 (15.6%) patients. Patients with severe pancreatitis were younger and had higher C-reactive protein levels than those with mild pancreatitis. The areas under the receiver operating characteristic curves of C-reactive protein levels at admission and 48 hours after diagnosis were 0.612 (95% confidence interval, 0.379-0.844) and 0.873 (95% confidence interval, 0.537-0.983), respectively. Fourteen patients (21.9%) experienced further episodes of recurrent pancreatitis. Patients with recurrent pancreatitis were older (13.7 vs 11.4 years, P = 0.022) and prominently boys (85.7 vs 52%, P = 0.022) compared with those without recurrence. Obesity was observed in 4 (0.6%) patients, which was confirmed in all recurrence groups and was statistically significant.
Conclusions:
This study demonstrated the feasibility of C-reactive protein in the early risk assessment of patients with acute pancreatitis and highlighted the potential risk of recurrence in patients with obesity.
More Related Videos
07:38Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
07:10Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
Related Concept Videos
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include: