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Fungicidal effectiveness of super-oxidized solution in vitro: potential implications for wound care
Ranjeni Krishnen1, Sreedharan Muniandy2
1Bactiguard (South East Asia), Simpang Ampat, Penang, Malaysia.
Introduction:
Drug-resistant fungal infections in chronic wounds represent a major clinical challenge to clinicians. Fungal infections delay wound healing by prolonging inflammation and encouraging biofilm formation, which protects microbes against host defenses and anti-infective medications. As such, interventions that prevent and control nosocomial fungal infections without interfering with the wound healing process are increasingly required. Although conventional antiseptics can effectively exert fungicidal effects, they also have adverse effects on human cells. SOS is a well-known bactericidal agent that enhances the wound healing process, especially for chronic wounds. However, few studies have evaluated the antimicrobial activity of SOS on fungi.
Objective:
The objective of this study was to evaluate whether SOS exerts fungicidal activities against common fungal species.
Materials And Methods:
The efficacy of SOS was tested against 6 fungal species (Candida albicans, Candida auris, Candida tropicalis, Candida parapsilosis, Sporothrix schenckii, Trichophyton mentagrophytes) using an in vitro time-kill assay.
Results:
SOS achieved 99.9999% reduction of all tested fungi within 1 minute of exposure.
Conclusions:
This study shows that SOS may be an effective tool for the prevention and control of fungal infections.
Insights
Silver oxysulfates (SOS) demonstrate potent fungicidal activity against common fungal species. This finding suggests SOS could be a valuable tool for managing fungal infections in chronic wounds.
Area of Science:
- Mycology
- Wound Healing
- Antimicrobial Agents
Background:
- Drug-resistant fungal infections pose a significant challenge in chronic wound care, delaying healing and forming biofilms.
- Conventional antiseptics can harm human cells, necessitating safer alternatives.
- Silver oxysulfates (SOS) are known for their bactericidal properties and wound healing enhancement, but their antifungal effects are understudied.
Purpose of the Study:
- To investigate the fungicidal efficacy of silver oxysulfates (SOS) against prevalent fungal species.
- To determine if SOS can be a viable option for controlling fungal infections in wound environments.
Main Methods:
- An in vitro time-kill assay was employed to assess SOS efficacy.
- Six fungal species were tested: Candida albicans, Candida auris, Candida tropicalis, Candida parapsilosis, Sporothrix schenckii, and Trichophyton mentagrophytes.
Main Results:
- SOS achieved a 99.9999% reduction in all tested fungal populations within one minute of exposure.
- This rapid and significant reduction indicates potent fungicidal activity.
Conclusions:
- Silver oxysulfates (SOS) exhibit strong fungicidal properties against a range of common fungal pathogens.
- SOS shows potential as an effective agent for preventing and controlling fungal infections in clinical settings, particularly in chronic wounds.
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