Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

492
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
492
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

68.8K
Overview
68.8K
What is the Immune System?01:38

What is the Immune System?

111.7K
Overview
111.7K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

870
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
870
T Cell Types and Functions01:24

T Cell Types and Functions

1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice.

Cell cycle (Georgetown, Tex.)·2011
Same author

Prediction of the postoperative pulmonary function in lung cancer patients with borderline function using ventilation-perfusion scintigraphy.

Nuclear medicine communications·2011
Same author

The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum.

Immunology·2011
Same author

Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12 cells via inhibition of ROS generation and Ca(2+) influx.

Neurotoxicology·2011
Same author

Quality-guided phase unwrapping technique: comparison of quality maps and guiding strategies.

Applied optics·2011
Same author

Nonlinear structured illumination microscopy by surface plasmon enhanced stimulated emission depletion.

Optics express·2011
Same journal

Corrigendum to "Eicosapentaenoic acid attenuates hyperoxia-induced lung injury via p38 MAPK/NF-κB-mediated regulation of glycolytic reprogramming" [Int. Immunopharmacol. 168(Part 2) (2026) 115903].

International immunopharmacology·2026
Same journal

ENOX1 promotes gastric cancer progression via Snail2-mediated epithelial-mesenchymal transition and M2-type tumour-associated macrophages polarisation.

International immunopharmacology·2026
Same journal

Esketamine protects against LPS-induced septic lung injury via NMDA receptor and NF-κB/NLRP3/Caspase-1/GSDMD pathway.

International immunopharmacology·2026
Same journal

Ganoderic acid A alleviates metabolic dysfunction-associated fatty liver disease through attenuating steatosis and cellular apoptosis by targeting acetyl-CoA carboxylase.

International immunopharmacology·2026
Same journal

Podophyllotoxin-induced nephrotoxicity via the microbiota-gut-kidney axis in SD rats based on the toxicological evidence chain (TEC) concept.

International immunopharmacology·2026
Same journal

The immunopharmacological role of B-cell and neutrophil-derived extracellular vesicles in pancreatic cancer: Mechanisms of inflammation, tumor progression, and potential therapeutic targets.

International immunopharmacology·2026
See all related articles

Related Experiment Video

Updated: Jul 17, 2025

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
05:27

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

4.3K

Gut immune microenvironment and autoimmunity.

Qiaolin Wang1, Qianjin Lu1, Sujie Jia2

  • 1Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing 210042, China.

International Immunopharmacology
|August 29, 2023
PubMed
Summary
This summary is machine-generated.

Gut microbiota and the gut immune microenvironment are crucial for maintaining health. Dysbiosis can disrupt this balance, contributing to autoimmune diseases and extra-intestinal disorders.

Keywords:
AutoimmunityGutGut-associated lymphoid tissuesImmune cellsIntestinal intraepithelial lymphocytes

More Related Videos

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.2K
Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
08:25

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Published on: November 21, 2018

13.7K

Related Experiment Videos

Last Updated: Jul 17, 2025

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
05:27

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

4.3K
Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.2K
Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
08:25

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Published on: November 21, 2018

13.7K

Area of Science:

  • Immunology
  • Microbiology
  • Gastroenterology

Background:

  • The gut houses a complex immune microenvironment essential for homeostasis.
  • Gut microbiota interact with immune cells to maintain gut immune balance.
  • Dysbiosis, or imbalance in gut microbiota, is linked to immune dysregulation.

Purpose of the Study:

  • To review the composition of the gut immune microenvironment.
  • To explore the association between the gut immune microenvironment and autoimmunity.
  • To provide insights into autoimmune disease pathogenesis and treatment.

Main Methods:

  • Literature review of existing studies on gut immunity and microbiota.
  • Analysis of the role of gut immune microenvironment in autoimmune conditions.
  • Discussion of mechanisms linking gut dysbiosis to extra-intestinal autoimmunity.

Main Results:

  • Gut microbiota dysbiosis disrupts immune homeostasis.
  • Imbalances in the gut immune microenvironment are associated with autoimmune diseases.
  • Migration of inflammatory cells from the gut can trigger extra-intestinal autoimmune disorders.

Conclusions:

  • The gut immune microenvironment and microbiota are critical in autoimmunity.
  • Understanding these interactions offers new therapeutic strategies for autoimmune diseases.
  • Targeting gut microbiota may prevent and treat autoimmune disorders.