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Patient-Reported Long-Term Outcome of Balloon Pulmonary Angioplasty for Inoperable CTEPH

Christoph B Wiedenroth1, Kristin Steinhaus2, Andreas Rolf3

  • 1Kerckhoff Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany.

The Thoracic and Cardiovascular Surgeon
|August 29, 2023
PubMed

Insights

Balloon pulmonary angioplasty (BPA) significantly improves long-term quality of life, symptoms, and activity in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). This study confirms BPA

Area of Science:

  • Cardiology
  • Pulmonology
  • Interventional Radiology

Background:

  • Balloon pulmonary angioplasty (BPA) is an emerging treatment for inoperable chronic thromboembolic pulmonary hypertension (CTEPH).
  • Long-term efficacy data for BPA in CTEPH are limited.
  • The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) tool assesses symptoms, activity, and quality of life (QoL).

Purpose of the Study:

  • To evaluate the long-term impact of BPA on symptoms, activity, and QoL in patients with inoperable CTEPH.
  • To assess the durability of BPA's effects using the CAMPHOR score.

Main Methods:

  • A prospective, observational study included 152 patients with inoperable CTEPH undergoing BPA.
  • CAMPHOR scores were collected at baseline and at 6 months post-intervention.
  • Annual follow-up CAMPHOR scores were assessed up to 250 weeks post-intervention.

Main Results:

  • Significant improvements were observed in CAMPHOR scores for symptoms (9 to 3, p<0.001), activity (8 to 4, p<0.001), and QoL (5 to 1, p<0.001) from baseline to the final follow-up.
  • These improvements were sustained over the long term.
  • The study included a median follow-up of 28 weeks and extended assessments up to 250 weeks.

Conclusions:

  • BPA provides significant and long-lasting improvements in symptoms, physical capacity, and QoL for patients with inoperable CTEPH.
  • The findings support BPA as an effective therapeutic option for managing inoperable CTEPH.
  • Long-term outcome data reinforce the benefits of BPA in improving patient well-being.
Abstract

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