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Updated: Jul 17, 2025

Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells
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Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells

Published on: December 17, 2012

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Examining SRP pathway function in mRNA localization to the endoplasmic reticulum.

Jessica R Child1, Alex C Hofler2, Qiang Chen1

  • 1Department of Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA.

RNA (New York, N.Y.)
|August 29, 2023
PubMed
Summary

The signal recognition particle (SRP) pathway is not essential for mRNA localization to the endoplasmic reticulum (ER). This study reveals that ER mRNA localization can occur independently of the SRP pathway, challenging existing models.

Keywords:
RNA localizationSRP receptorendoplasmic reticulummRNAribosome

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