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Bifidobacteria in disease: from head to toe.
Weiliang Zhang1, Qiang Jia2, Mingming Han2
1Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong, China.
Folia Microbiologica
|August 29, 2023
Summary
Bifidobacteria, crucial gut bacteria, are vital for health. Their imbalance (dysbiosis) links to various diseases, suggesting therapeutic potential beyond the gut.
Area of Science:
- Microbiology
- Gut Microbiome Research
- Human Health
Background:
- Bifidobacteria are essential anaerobic, gram-positive bacteria colonizing the gut, oral cavity, and vagina early in life.
- Intestinal flora, particularly Bifidobacteria, plays a critical role in maintaining health; dysbiosis is associated with numerous diseases.
- Emerging evidence indicates Bifidobacteria's influence extends beyond the gut, impacting the nervous, respiratory, and genitourinary systems.
Purpose of the Study:
- To review the role of Bifidobacteria in various systemic diseases.
- To explore Bifidobacteria as potential therapeutic agents for challenging conditions.
- To bridge the gap between Bifidobacteria research and clinical practice.
Main Methods:
- Comprehensive literature review of studies on Bifidobacteria and disease.
- Analysis of evidence linking Bifidobacteria variations to specific pathologies across different body systems.
- Identification of therapeutic strategies involving Bifidobacteria.
Main Results:
- Bifidobacteria dysregulation is observed in diverse diseases affecting multiple organ systems.
- Bifidobacteria contribute to maintaining intestinal homeostasis and influence extra-intestinal health.
- Evidence supports Bifidobacteria's potential in managing various non-intestinal diseases.
Conclusions:
- Bifidobacteria are key players in systemic health, not just intestinal balance.
- Modulating Bifidobacteria populations offers promising therapeutic avenues for complex diseases.
- Further clinical research is warranted to translate findings into effective treatments.
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