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Published on: September 9, 2011
Experimental investigation of biostimulatory effects after polydioxanone thread insertion in a pig model
Diya Su1, Shiwei Wang2, Tong He2
1Department of Plastic Surgery, Xinhua Hospital Affiliated to Dalian University, Dalian, China.
Background:
Polydioxanone (PDO) threads have been widely used to tighten and lift the facial soft tissue.
Objective:
This research aims to determine the collagenation and inflammation changes that occur in the adipose tissue over time when different types of threads are implanted.
Methods & Materials:
Three threads types, PDO, poly glycolic-co-lactic acid (PGLA), and nylon, were inserted in the subcutaneous fat of 12-month-old Bama miniature pigs. Collagen production and inflammatory response were evaluated by hematoxylin and eosin and Masson trichrome staining at 1, 4, 12, 24, and 48 weeks.
Results:
The integrity of the PDO thread lasted up to 24 weeks with mild inflammation and collagen production. The PGLA thread integrity lasted until 12 weeks and had a strong inflammatory response. The nylon thread's integrity was maintained for 48 weeks and showed minor inflammation and collagen production.
Conclusion:
Our data suggest that PDO thread is the best choice for clinicians, as it has a mild action process with minimal irritation, moderate collagen production, a reasonable explanation time, with obvious bridging fibrous tissue, and thickening action for the superficial fascia.
