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DVT as the Initial Presentation of Multiple Myeloma: A Rare Case Report and Literature Review
Sondos K Khalil1, Leena Saeed1, Abdalla Fadul1
1Internal Medicine Department, Hamad Medical Corporation, Doha, QAT.
Abstract:
Multiple myeloma patients are recognized to have a higher risk of venous thrombosis. The cause of this could be attributed to several risk factors, such as circulating prothrombotic microparticles, disease-specific variables, and alterations in coagulation and fibrinolysis factors. Recent research has revealed that these individuals also experience greater arterial thrombosis, including acute myocardial infarction and stroke. In this case report, we present the clinical profile and management of a 42-year-old patient who presented with signs and symptoms of deep venous thrombosis (DVT) and was diagnosed with multiple myeloma. The aim of this case report is to highlight a rare clinical presentation and diagnostic workup in a patient with multiple myeloma. Additionally, we discuss the possible factors provoking the development of DVT as a first presentation before treatment initiation and their possible mechanisms.
Insights
Multiple myeloma patients face increased risk of venous thrombosis due to disease factors. This case highlights deep venous thrombosis (DVT) as an initial symptom in a 42-year-old patient.
Area of Science:
- Hematology
- Oncology
- Vascular Medicine
Background:
- Multiple myeloma (MM) patients exhibit elevated risk for venous thromboembolism (VTE).
- Prothrombotic microparticles, disease factors, and coagulation/fibrinolysis alterations contribute to thrombosis risk in MM.
- Arterial thrombosis, including myocardial infarction and stroke, is also more prevalent in MM patients.
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