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Updated: Jul 17, 2025

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
Published on: November 13, 2021
Foresight in clinical proteomics: current status, ethical considerations, and future perspectives.
Filip Mundt1, Nicolai J Wewer Albrechtsen1,2, Sebastian Porsdam Mann3
1Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Clinical proteomics is advancing rapidly, offering new diagnostic and treatment strategies. Addressing ethical challenges is crucial for integrating large-scale proteomics data into patient care and research.
Area of Science:
- Proteomics
- Clinical Research
- Bioinformatics
Background:
- Proteomics technologies and bioinformatics tools enable large-scale data analysis in life sciences.
- Proteins are key targets for over 95% of FDA-approved drugs and most diagnostic tests.
Discussion:
- Leaders convened at the CTLS conference, discussing the clinical implementation of proteomics.
- Key topics included the current status, challenges, and future directions for clinical proteomics.
Key Insights:
- Clinical proteomics is emerging for patient stratification and treatment guidance.
- Ethical considerations are paramount for handling large-scale clinical proteomics data.
Outlook:
- Recommendations are provided for the ethical and effective implementation of clinical proteomics.
- Efforts are needed to establish proteomics as a mainstream technology in translational and clinical research.
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