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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
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Dysfunctional high-density lipoprotein in chronic inflammatory rheumatic diseases
Sabina Waldecker-Gall1, Felix Seibert2, Sebastian Bertram2
1Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Germany.
Therapeutic Advances in Musculoskeletal Disease
|August 30, 2023
Summary
Chronic inflammatory rheumatic disease (CIRD) is linked to higher oxidized high-density lipoprotein (HDLox), indicating impaired HDL function. Treatment reduced HDLox, suggesting improved cardiovascular health in CIRD patients.
Area of Science:
- Rheumatology
- Cardiovascular Disease
- Lipid Metabolism
Background:
- The mechanisms behind low cholesterol in chronic inflammatory rheumatic diseases (CIRD) are not fully understood.
- Chronic inflammation may impair high-density lipoprotein (HDL) functionality through oxidative processes.
Purpose of the Study:
- To assess oxidized HDL (HDLox), a marker of HDL dysfunction, in newly diagnosed CIRD patients.
- To compare HDLox levels in CIRD patients before and after immunosuppressive therapy with non-CIRD controls.
Main Methods:
- A prospective observational trial involving 44 newly diagnosed CIRD patients and 136 controls.
- Measurements included lipid profiles, HDLox, and C-reactive protein (CRP) at baseline and 12 weeks for CIRD patients.
- Disease activity and function were assessed using validated tools.
Main Results:
- CIRD patients exhibited significantly higher HDLox concentrations compared to controls (1.57 vs. 0.78, p=0.02).
- CIRD patients showed trends towards lower LDL, HDL, and total cholesterol levels.
- HDLox and CRP levels decreased in CIRD patients after 12 weeks of immunosuppressive therapy.
Conclusions:
- CIRD is associated with impaired HDL anti-inflammatory properties, evidenced by increased HDLox.
- Elevated HDLox may contribute to the heightened cardiovascular risk observed in chronic inflammatory diseases.
Keywords:
axial spondyloarthritiscardiovascular riskinflammationoxidized high-density lipoproteinrheumatic diseaserheumatoid arthritisMore Related Videos
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