Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.1K
DNA Microarrays02:34

DNA Microarrays

17.5K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
17.5K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

34.6K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.6K
What is Gene Expression?01:36

What is Gene Expression?

8.6K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
8.6K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

943
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
943

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EpiATLAS - a reference for human epigenomic research.

bioRxiv : the preprint server for biology·2026
Same author

Transient blood-brain barrier opening by focused ultrasound enhances ferumoxytol accumulation in glioblastoma.

Materials today. Bio·2026
Same author

Quantitative detection of macrophage activation in osteosarcoma comparing <sup>18</sup>F-FDG PET/CT with ferumoxytol-enhanced MRI.

Scientific reports·2026
Same author

T cell-specific loss of IRF1 results in defective CD8 T cell activation and antitumor immunity.

bioRxiv : the preprint server for biology·2026
Same author

Initial leukemic epigenomic state determines hypomethylating agent response.

Nature communications·2026
Same author

How does AI perform compared to human expert panels in medical Delphi studies? A pilot study through the lens of pathology.

Journal of pathology informatics·2026

Related Experiment Video

Updated: Jul 17, 2025

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

18.8K

"iNETgrate": integrating DNA methylation and gene expression data in a single gene network.

Sogand Sajedi1,2, Ghazal Ebrahimi3, Raheleh Roudi4

  • 1Department of Cell Systems & Anatomy, The University of Texas Health Science Center, San Antonio, Texas 78229, USA.

Research Square
|August 30, 2023
PubMed
Summary

We developed iNETgrate to integrate transcriptome and DNA methylation data, improving cancer patient prognostication. This novel gene network approach enhances statistical power for multi-omics analysis.

More Related Videos

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
13:21

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

10.1K
Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.0K

Related Experiment Videos

Last Updated: Jul 17, 2025

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

18.8K
Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
13:21

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

10.1K
Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.0K

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Integrating multi-omics data, such as transcriptome and DNA methylation, can enhance statistical power in biological research.
  • Designing integrated models is challenging due to the heterogeneity of different omics data types.
  • Existing methods may not fully leverage the potential of combined multi-omics data for complex biological questions.

Conclusions:

  • iNETgrate provides an effective solution for integrating multi-omics data.
  • The package enhances biological insights and predictive capabilities, particularly in cancer prognostication.
  • This approach offers a powerful tool for researchers working with complex genomic and epigenomic datasets.