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Updated: Jul 17, 2025

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
Published on: July 12, 2012
"iNETgrate": integrating DNA methylation and gene expression data in a single gene network
Sogand Sajedi1,2, Ghazal Ebrahimi3, Raheleh Roudi4
1Department of Cell Systems & Anatomy, The University of Texas Health Science Center, San Antonio, Texas 78229, USA.
Abstract:
Integrating multi-omics data in one model can increase statistical power. However, designing such a model is challenging because different omics are measured at different levels. We developed the iNETgrate package (https://bioconductor.org/packages/iNETgrate/) that efficiently integrates transcriptome and DNA methylation data in a single gene network. Applying iNETgrate on five independent datasets improved prognostication compared to common clinical gold standards and a patient similarity network approach.
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