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Updated: Jul 17, 2025

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
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Published on: October 5, 2014

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Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting

Alexander Kapustin1, Sofia Serena Tsakali1, Meredith Whitehead1

  • 1School of Cardiovascular and Metabolic Medicine & Sciences, James Black Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.

Biorxiv : the Preprint Server for Biology
|August 30, 2023
PubMed
Summary

Fibronectin (FN) accumulation in blood vessels stimulates vascular smooth muscle cells (VSMCs) to release extracellular vesicles (sEVs). These sEVs, enriched with collagen VI, promote cell adhesion and invasion, crucial for vascular repair and atherosclerosis.

Keywords:
cell adhesionsmall extracellular vesiclesvascular remodelling

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