Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes.

Immunity·2026

Same author

Modulation of Ferroptosis During Early <i>Mycobacterium tuberculosis</i> Infection Contributes to Beijing Lineage Strain SA161 Virulence.

bioRxiv : the preprint server for biology·2026

Same author

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.

Nature communications·2026

Same author

Single-cell profiling reveals that dynamic lung immune responses distinguish protection from susceptibility to tuberculosis.

PLoS pathogens·2026

Same author

High-Resolution Quantification of Two-Way Nanobody Synergy Using Automated Liquid Handling and Computational Modeling.

Bio-protocol·2026

Same author

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

bioRxiv : the preprint server for biology·2026

Same journal

Genetic Impacts on Variability of Body Fat Distribution Uncover Gene-Environment and Gene-Gene Interactions.

bioRxiv : the preprint server for biology·2026

Same journal

16S ribosomal RNA modification drives transcript-specific translation efficiency.

bioRxiv : the preprint server for biology·2026

Same journal

FlcE latches onto the FliL-stator complex to turbocharge flagellar motility in <i>Borrelia burgdorferi</i>.

bioRxiv : the preprint server for biology·2026

Same journal

Synaptic pruning, myelination and the emergence of psychiatric disorders in late adolescence.

bioRxiv : the preprint server for biology·2026

Same journal

Structural and functional insights into the Rcs phosphorelay.

bioRxiv : the preprint server for biology·2026

Same journal

The structural basis of RanGAP1 regulation and catalysis in nuclear transport.

bioRxiv : the preprint server for biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 17, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

Predicting host-based, synthetic lethal antiviral targets from omics data.

Jeannette P Staheli¹, Maxwell L Neal¹, Arti Navare¹

¹Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, 98101, USA.

Biorxiv : the Preprint Server for Biology

|August 30, 2023

Summary

This summary is machine-generated.

Researchers identified new host-based antiviral targets by analyzing synthetic lethal (SL) interactions. This approach leverages CRISPR knockout screens and omics data to find vulnerabilities in virus-infected cells, offering a promising strategy for broad-spectrum antiviral drug development.

More Related Videos

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

Related Experiment Videos

Last Updated: Jul 17, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

Area of Science:

Virology
Computational Biology
Drug Discovery

Background:

Traditional antiviral therapies face challenges with toxicity and drug resistance.
Host-based antivirals offer an alternative but can cause non-specific effects.
Targeting synthetic lethal (SL) partners of virus-disrupted proteins presents a novel strategy for selective cell elimination.

Conclusions:

CRISPR KO data contain numerous common antiviral targets due to their SL relationship with virus-altered cellular states.
Analysis of omics datasets combined with SL predictions can uncover these broad-spectrum antiviral targets.
This approach offers a promising avenue for developing novel host-based antiviral therapies.