Related Experiment Video
Updated: Jul 17, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
11.5K
MicroRNAs and Periodontal Disease: Helpful Therapeutic Targets?
Abdolhakim Palideh1, Mostafa Vaghari-Tabari2,3, Ali Nosrati Andevari4
1Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Advanced Pharmaceutical Bulletin
|August 30, 2023
Summary
MicroRNAs (miRNAs) are crucial in periodontal disease development, influencing immune responses and gum tissue. These small molecules show therapeutic potential for treating this common inflammatory oral condition.
Area of Science:
- Oral Biology
- Immunology
- Molecular Biology
Background:
- Periodontal disease is a prevalent inflammatory oral condition.
- Bacterial accumulation at the gum line triggers an immune response central to disease pathogenesis.
- Periodontal ligament and gingival epithelial cells contribute to disease progression.
Purpose of the Study:
- To comprehensively review and discuss the role of microRNAs (miRNAs) in the immunopathogenesis of periodontal disease.
- To explore the relationship between miRNAs, the immune system, and periodontium tissues.
Main Methods:
- Literature review of recent studies on miRNAs in periodontal disease.
- Analysis of the immunomodulatory functions of miRNAs in the context of periodontitis.
Main Results:
- miRNAs, small RNA molecules, significantly interact with the immune system.
- These molecules are closely associated with periodontium tissues, particularly periodontal ligament cells.
- Extensive research highlights the involvement of miRNAs in the pathogenesis of periodontal disease.
Conclusions:
- miRNAs play a significant role in the immunopathogenesis of periodontal disease.
- miRNAs represent promising therapeutic targets for future periodontal disease treatments.
Related Concept Videos
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
01:29Microorganisms in Medicine and Therapeutics
53
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
53
01:28Gene Regulation in Microbial Communities: Quorum Sensing
39
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
39