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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Advances in immunotherapy for biliary tract cancers
Yuhao Zhao1,2,3, Mao Yang1,2,3, Jiayi Feng1,2,3
1Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Immunotherapy shows promise for advanced biliary tract cancers (BTC) like gallbladder cancer. This review details recent immunotherapy advances and ongoing clinical trials for BTC treatment.
Area of Science:
- Oncology
- Immunology
Background:
- Biliary tract cancers (BTC) encompass gallbladder cancer (GBC), intrahepatic cholangiocarcinoma (ICC), and extrahepatic cholangiocarcinoma (ECC), characterized by poor prognosis.
- Most BTC patients present at advanced stages, precluding surgical treatment, thus necessitating non-surgical therapeutic strategies.
Conclusions:
- Immunotherapy represents a significant area of research for improving outcomes in advanced BTC.
- Further clinical investigation is crucial to establish the role of different immunotherapies in BTC management.
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