Related Experiment Video
Updated: Jul 17, 2025
10:37
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
211
Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community-Based Study
Jingli Gao1, Yang Liu2, Ning Ning2
1Department of Intensive Care Unit Kailuan General Hospital Tangshan Hebei China.
Journal of the American Heart Association
|August 30, 2023
Summary
Higher Life's Essential 8 (LE8) scores are linked to a reduced risk of diabetic kidney disease (DKD). This study demonstrates that improving cardiovascular health through LE8 positively impacts renal health in diabetes patients.
Area of Science:
- Cardiovascular Health
- Nephrology
- Endocrinology
Background:
- Diabetic kidney disease (DKD) is a prevalent complication of diabetes, complicating management.
- No prior prospective studies have investigated the association between Life's Essential 8 (LE8) and DKD risk.
Purpose of the Study:
- To examine the association between Life's Essential 8 (LE8) scores and the risk of developing diabetic kidney disease (DKD).
Main Methods:
- Longitudinal and trajectory analyses included 7605 and 4688 participants, respectively, from 2006-2020.
- LE8 scores, based on 8 health metrics (4 behaviors, 4 factors), were assessed. DKD was confirmed via follow-up data.
- Latent mixture models classified LE8 trajectories, and Cox models with restricted cubic splines analyzed associations.
Main Results:
- DKD incidence decreased as LE8 scores increased (P-trend<0.05).
- The highest tertile of LE8 scores showed reduced DKD risk (HR 0.77, 0.70) compared to the lowest tertile.
- A stable-high LE8 pattern significantly lowered DKD risk (HR 0.53) versus a stable-low pattern.
Conclusions:
- Life's Essential 8 (LE8) is a valuable indicator for cardiovascular health.
- Elevated LE8 scores demonstrate a protective effect on renal health in individuals with diabetes.
- Improving overall cardiovascular health via LE8 contributes to mitigating diabetic kidney disease risk.
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
34
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
34
01:28Chronic Kidney Disease III: Interprofessional Care
42
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
42
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
11
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
11
01:18Chronic Kidney Disease IV: Nursing Management
25
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
25
01:24Chronic Kidney Disease II: Clinical Manifestations
29
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
29
01:15Diabetes: Symptoms, Diagnosis, and Complications
588
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
588