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Prognostic Value of Multiple Complete Blood Count-Derived Indices in Intermediate Coronary Lesions

Yuxiu Yang1, Chenxi Song1, Lei Jia1

  • 1Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Angiology
|August 30, 2023
PubMed

Insights

The Systemic Inflammation Response Index (SIRI) is a key inflammatory biomarker for predicting major adverse cardiovascular events in patients with intermediate coronary stenosis. SIRI and AISI showed the strongest prognostic value, enhancing risk prediction beyond traditional models.

Area of Science:

  • Cardiology
  • Inflammation Biomarkers
  • Predictive Analytics

Background:

  • Complete blood count (CBC)-derived indices are emerging as potential inflammatory biomarkers for cardiovascular disease outcomes.
  • Validation of these indices in patients with intermediate coronary stenosis is limited.

Purpose of the Study:

  • To evaluate the prognostic value of various CBC-derived inflammatory indices in patients with intermediate coronary stenosis.
  • To identify the most effective index for predicting major adverse cardiovascular events (MACEs).

Main Methods:

  • A cohort of 1527 patients with intermediate coronary stenosis was analyzed.
  • Neutrophil-lymphocyte ratio (NLR), derived NLR, monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), systemic immune inflammation index (SII), system inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) were examined.
  • The primary endpoint was a composite of MACEs over a median follow-up of 6.11 years.

Main Results:

  • The Systemic Inflammation Response Index (SIRI) demonstrated the highest predictive power, evidenced by the largest area under the receiver operator characteristic curve.
  • In multivariable analysis, SIRI (HR 1.588) and Aggregate Index of Systemic Inflammation (AISI) (HR 1.673) were significant independent predictors of MACEs.
  • Predictive performance of these indices improved in patients with a lower burden of modifiable cardiovascular risk factors, with SIRI offering the best incremental value.

Conclusions:

  • CBC-derived indices, particularly SIRI and AISI, are valuable prognostic markers for MACEs in patients with intermediate coronary stenosis.
  • SIRI shows superior performance and incremental predictive value compared to other inflammatory indices and traditional risk models.
  • These findings support the use of SIRI in risk stratification for patients with intermediate coronary stenosis.

Keywords:
Complete blood count-derived inflammatory indicesatherosclerosisinflammationintermediate coronary stenosis

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