Pre-whitened matched filter and convolutional neural network based model observer performance for mass lesion...

Mathematical model observers have been shown to reasonably predict human observer performance and are useful when human observer studies are infeasible. Recently, convolutional neural networks (CNNs) have also been used as substitutes for human observers, and studies have shown their utility as an optimal observer. In this study, a CNN model observer is compared to the pre-whitened matched filter (PWMF) model observer in detecting simulated mass lesions inserted into 253 acquired breast computed tomography (bCT) images from patients imaged at our institution.

To compare CNN and PWMF model observers for detecting signal-known-exactly (SKE) location-known-exactly (LKE) simulated lesions in bCT images with real anatomical backgrounds, and to use these model observers collectively to optimize parameters and understand trends in performance with breast CT.

Spherical lesions with different diameters (1, 3, 5, 9 mm) were mathematically inserted into reconstructed patient bCT image data sets to mimic 3D mass lesions in the breast. 2D images were generated by extracting the center slice along the axial dimension or by slice averaging across adjacent slices to model thicker sections (0.4, 1.2, 2.0, 6.0, 12.4, 20.4 mm). The role of breast density was retrospectively studied using the range of breast densities intrinsic to the patient bCT data sets. In addition, mass lesions were mathematically inserted into Gaussian images matched to the mean and noise power spectrum of the bCT images to better understand the performance of the CNN in the context of a known ideal observer (the PWMF). The simulated Gaussian and bCT images were divided into training and testing data sets. Each training data set consisted of 91 600 images, and each testing data set consisted of 96 000 images. A CNN and PWMF was trained on the Gaussian training images, and a different CNN and PWMF was trained on the bCT training images. The trained model observers were tested, and receiver operating characteristic (ROC) curve analysis was used to evaluate detection performance. The area under the ROC curve (AUC) was the primary performance metric used to compare the model observers.

In the Gaussian background, the CNN performed essentially identically to the PWMF across lesion sizes and section thicknesses. In the bCT background, the CNN outperformed the PWMF across lesion size, breast density, and most section thicknesses. These findings suggest that there are higher-order features in bCT images that are harnessed by the CNN observer but are inaccessible to the PWMF.

The CNN performed equivalently to the ideal observer in Gaussian textures. In bCT background, the CNN captures more diagnostic information than the PWMF and may be a more pertinent observer when conducting optimal performance studies in breast CT images.