EUS-guided Gastroenterostomy: A Multicenter International Study Comparing Benign and Malignant Diseases

Area of Science:

• Gastroenterology
• Minimally Invasive Procedures
• Endoscopic Ultrasound

Background:

• Endoscopic ultrasound (EUS)-guided gastroenterostomy (EUS-GE) is a minimally invasive option for gastric outlet obstruction.
• It avoids surgical bypass risks and limitations of enteral stents.
• Limited data exists on EUS-GE outcomes based on underlying disease etiology.

Purpose of the Study:

• To compare the long-term outcomes of EUS-GE in patients with benign versus malignant indications.
• To evaluate adverse events, technical success, and clinical success rates.

Main Methods:

• Retrospective registry analysis of consecutive patients from 12 international centers over 3 years.
• Data collected included demographics, procedure details, and follow-up information.
• Primary outcome: adverse event rates; Secondary outcomes: technical/clinical success, hospitalization.

Main Results:

• 103 patients included: 72 malignant, 31 benign.
• EUS-GE demonstrated similar clinical success, technical success, procedure time, and hospital stay for both groups.
• Patients with benign etiology had a higher incidence of surgically altered midgut anatomy (P=0.0379).

Conclusions:

• EUS-GE is an effective treatment for gastric outlet obstruction irrespective of whether the cause is benign or malignant.
• Adverse event rates were comparable between benign and malignant indications.