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Updated: Aug 2, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
[Use of immunoglobulin for treating patients with nonspecific ulcerative colitis]
Abstract:
The therapeutic effect of human immunoglobulins was assessed in 29 patients with nonspecific ulcerative colitis, as was their influence on intestinal flora. A 5 to 15 ml dose of immunoglobulin was administered intramuscularly every other day, 3 injections altogether. The clinical and endoscopic effect of treatment was positive in 21 patients (72.4%). Large-intestinal mucosal imprints were studied histologically in 17 patients. Inflammation subsided in 11 patients (64.7%), and glandular epithelial proliferation declined in 4 (23.5%). In the course of treatment, lactobacilli, and bifidobacteria were considerably increased in number, while opportunity organisms were decreased, a possible cause of the positive clinical effect.
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