Related Experiment Video
Updated: Jul 17, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Severe hemolytic exacerbations of Chinese PNH patients infected SARS-CoV-2 Omicron
Hui Yang1, Xingxing Chai2, Yuemin Gong1
1Key Laboratory of Hematology of Nanjing Medical University, Department of Hematology, Collaborative Innovation Center for Cancer Personalize, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu, China.
Introduction:
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by hemolytic anemia, bone marrow failure, thrombophilia. COVID-19, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with many variants including Omicron.
Methods:
This study collected demographic and clinical data of 20 PNH patients with SARS-CoV-2 Omicron infection.
Results:
They all were with high disease activity, and LDH level exceeded any documented since the diagnosis of PNH, and those reported in the literature for previously stable treatment with complement inhibitors. D-dimer level elevated in 10 patients. 2 patients developed mild pulmonary artery hypertension. Glomerular filtration rate declined in 5 patients. 1 patient developed acute renal failure and underwent hemodialysis. Anemia and hemolysis were improved in 5 patients treated with eculizumab.
Conclusions:
Hemolytic exacerbation of PNH with COVID-19 is severe and eculizumab may be an effective treatment.
More Related Videos
09:02Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
10:25Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Pneumonia II: Pathophysiology
Acute Pyelonephritis II: Diagnostic Studies and Management
Pneumonia III: Complications and Assessment