Related Experiment Videos
[Kidney function and the effectiveness of hypotensive therapy of patients with hypertension]
Insights
Detecting specific carbonic esterase isoenzymes (CE5-7) in urine indicates poor prognosis for hypertension patients with ischemic renal lesions. Certain blood pressure medications improved outcomes, unlike propranolol.
Area of Science:
- Nephrology
- Cardiology
- Clinical Chemistry
Background:
- Hypertension is a major risk factor for ischemic renal lesions.
- Early diagnosis and appropriate treatment are crucial for managing hypertensive nephropathy.
- Carbonic esterases (CE) and their isoenzymes play roles in renal physiology and pathology.
Purpose of the Study:
- To investigate the diagnostic and prognostic value of slow carbonic esterase isoenzymes (CE5-7) in urine for ischemic renal lesions in hypertensive patients.
- To evaluate the impact of different antihypertensive medications on renal outcomes in these patients.
Main Methods:
- Diagnosis of ischemic renal lesions in 108 hypertensive patients.
- Urine analysis for the detection of slow carbonic esterase isoenzymes (CE5-7).
- Assessment of therapeutic outcomes with various antihypertensive drugs, including propranolol and others affecting renal blood flow.
Main Results:
- Detection of urinary carbonic esterase isoenzymes (CE5-7) was a poor prognostic indicator.
- Propranolol use was associated with deteriorating renal circulation.
- Antihypertensive drugs that did not impair or improved renal blood flow (e.g., dopegyt, chlophelin, reserpine, apressin, corinfar, isoptin) showed more promising results.
Conclusions:
- Urinary CE5-7 isoenzymes are valuable markers for poor prognosis in hypertensive patients with ischemic renal lesions.
- Medication choice is critical; drugs improving renal blood flow are preferred over those potentially worsening it, such as propranolol.
Abstract:
Ischemic renal lesion in 108 patients with hypertension was diagnosed by means of the determination of slow isoenzymes of carbonic esterases (CE5-7) in the urine. Their detection was a poor prognostic sign for any therapeutic method, particularly with the use of propranolol deteriorating renal circulation. The use of drugs not deteriorating or improving the renal blood flow (dopegyt, chlophelin, reserpine, apressin, corinfar, isoptin) brought about more promising results in such cases.