Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Integration of Synaptic Events

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

Neural Circuits

Neural Circuits

Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...

Organization of the Brain

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Expansion-Assisted Hybridization Chain Reaction-smFISH and Immunohistochemistry in Drosophila Brain.

Journal of visualized experiments : JoVE·2026

Same author

A transcriptomic axis aligns with in vivo functional dynamics in hippocampal inhibitory circuits.

bioRxiv : the preprint server for biology·2026

Same author

Organization and evolution of sex-biased gene expression in <i>Drosophila</i> adult sexual circuits.

bioRxiv : the preprint server for biology·2026

Same author

Remote and partial clocks expand the circadian neuronal network, driving widespread molecular rhythmicity in <i>Drosophila</i>.

bioRxiv : the preprint server for biology·2026

Same author

Parallel neuronal ensembles control behavior across sensorimotor levels in <i>Drosophila</i>.

bioRxiv : the preprint server for biology·2025

Same author

Electrical synapses mediate visual approach behavior.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Jul 17, 2025

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Brain wiring determinants uncovered by integrating connectomes and transcriptomes.

Juyoun Yoo¹, Mark Dombrovski², Parmis Mirshahidi²

¹Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Current Biology : CB

|August 30, 2023

Summary

This summary is machine-generated.

Researchers identified specific cell adhesion molecule (CAM) pairs, Beat and Side, that guide precise neural connections in the Drosophila visual system, revealing key mechanisms for brain wiring specificity.

Keywords:

Drosophila brain wiring connectome interactome receptor-ligand synaptic specificity transcriptome visual system

More Related Videos

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Published on: March 31, 2022

Related Experiment Videos

Last Updated: Jul 17, 2025

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Published on: March 31, 2022

Area of Science:

Neuroscience
Developmental Biology
Genetics

Background:

Brain connectomics reveals intricate neural circuit complexity.
Cell adhesion molecules (CAMs) mediate neurite interactions during circuit assembly.
Identifying specific CAM receptor-ligand pairs for synaptic targeting remains a challenge.

Purpose of the Study:

To identify specific receptor-ligand pairs of CAMs that mediate target selection in the Drosophila visual system.
To understand how these pairs contribute to the precise wiring of neural circuits.

Main Methods:

Integrated synapse-level connectome data with developmental expression patterns and binding specificities of CAMs.
Focused on genetically related neurons with differential wiring choices in the motion detection circuit.
Utilized genetic analysis to investigate the function of specific CAMs.

Main Results:

Identified matching expression of Beat and Side family CAMs in synaptic partners of T4/T5 neuron subtypes.
Demonstrated that presynaptic Side-II and postsynaptic Beat-VI restrict synaptic partners to adjacent neuropil layers.
Showed that removal of this pair disrupts layer formation and causes aberrant targeting.

Conclusions:

Specific Side/Beat CAM receptor-ligand pairs collaborate to determine wiring specificity in the fly brain.
Combining transcriptomic, connectomic, and protein interaction data enables unbiased identification of wiring determinants.