Osmoregulatory Challenges Faced by Mosquitoes and Techniques for Studying the Transporters Involved in Their...

Mosquitoes are the most important disease vector in the world, and gaining knowledge of their physiology to develop novel population control strategies has been a focus of research for some time. Both aquatic larvae and terrestrial adults face harsh environmental factors that severely challenge their salt and water balance, which are regulated by the function of epithelia of various organs. The regulated passage of water and solutes across epithelia occurs, in part, through transporters expressed in epithelial cell membranes. Identifying these transporters and their localization is necessary to understand how mosquitoes regulate salt and water balance. Here, we review environmental challenges faced by mosquitoes and how they cope with them, in addition to introducing techniques used to identify organ epithelial transporters.