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Neuroplasticity

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Related Experiment Video

Updated: Jul 17, 2025

Author Spotlight: Investigating Vocal Information Representation in Small Primates and Its Alteration by Psychiatric Disorders Using Noninvasive EEG

Author Spotlight: Investigating Vocal Information Representation in Small Primates and Its Alteration by Psychiatric Disorders Using Noninvasive EEG

Published on: July 26, 2024

Rapid, Activity-Dependent Intrinsic Plasticity in the Developing Zebra Finch Auditory Cortex.

Yao Lu¹, Francesca Sciaccotta¹, Leah Kiely¹

¹Psychology Department.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|August 30, 2023

Summary

This summary is machine-generated.

Auditory experience in young zebra finches rapidly alters neuronal firing dynamics in the caudal mesopallium (CM). This intrinsic plasticity involves the K_v1.1 channel and is crucial for auditory learning in complex environments.

Keywords:

Kv1.1 activity-dependent plasticity auditory learning intrinsic dynamics zebra finch

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Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain

Published on: October 11, 2017

Area of Science:

Neuroscience
Auditory System Development
Cellular Plasticity

Background:

Early-life acoustic environments shape auditory system development.
Experience-dependent plasticity primarily involves synaptic changes, but intrinsic neuronal properties may also contribute.
The mechanisms and roles of intrinsic neuronal plasticity are not well understood.

Purpose of the Study:

To investigate intrinsic neuronal plasticity in the zebra finch auditory cortex (caudal mesopallium, CM).
To determine the role of the low-threshold potassium channel K_v1.1 in experience-dependent intrinsic plasticity.
To explore the contribution of intrinsic plasticity to auditory learning in complex acoustic environments.

Main Methods:

Electrophysiological recordings from CM neurons in juvenile male and female zebra finches.
Analysis of K_v1.1 channel expression in plasma membrane and endoplasmic reticulum (ER).
Manipulation of neuronal activity, potassium currents, and intracellular calcium signaling.

Main Results:

CM neurons exhibited rapid changes in firing dynamics in birds reared in complex acoustic environments.
This intrinsic plasticity was associated with increased K_v1.1 expression in the plasma membrane and ER.
Plasticity depended on neuronal activity, was reversible by blocking low-threshold potassium currents, and required intracellular calcium signaling.

Conclusions:

Activity-dependent elevation of intracellular calcium rapidly mobilizes K_v1.1 to the plasma membrane.
This K_v1.1-mediated plasticity shifts neuronal excitability and temporal integration in CM neurons.
This mechanism may facilitate auditory learning during critical periods of vocal perception and production development.