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Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Editing a rice CDP-DAG synthase confers broad-spectrum resistance
Xiaoman You1, Yuese Ning1, Guo-Liang Wang2
1State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
None:
Lesion mimic mutations (LMMs) often confer broad-spectrum resistance (BSR) in plants, but with significant yield penalties. Sha et al. recently demonstrated that genome editing of the rice BSR gene RESISTANCE TO BLAST1 (RBL1), encoding a cytidine diphosphate diacylglycerol (CDP-DAG) synthase involved in phospholipid biosynthesis, confers multipathogen resistance without an obvious trade-off in yield.
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