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Updated: Jul 17, 2025
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Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent
Published on: June 5, 2019
6.5K
Quantifying ventilation by X-ray velocimetry in healthy adults
Trishul Siddharthan1, Kyle Grealis2, Jason P Kirkness3
1Division of Pulmonary, Critical Care, and Sleep Medicine, University of Miami, Miami, FL, USA. tsiddhar@miami.edu.
Respiratory Research
|August 30, 2023
Summary
X-ray velocimetry (XV) shows good agreement with conventional methods for measuring respiratory rate and duty cycle. Adjustments improve XV accuracy for tidal volume and flow rate, especially during assisted breathing.
Area of Science:
- Pulmonary physiology
- Medical imaging analysis
- Respiratory mechanics
Background:
- X-ray velocimetry (XV) is used in preclinical models to assess lung motion and regional ventilation.
- No prior studies have compared XV-derived physiologic parameters to conventional measures.
Purpose of the Study:
- To assess agreement between XV analysis of fluoroscopic lung images and pitot tube flowmeter measures of ventilation.
- To compare XV and pitot tube measurements during tidal and bilevel-assisted breathing.
Main Methods:
- Ventilatory parameters derived from XV and pitot tube were compared.
- Bland-Altman analysis assessed agreement levels.
- Mixed models characterized associations and optimized XV values for higher volumes.
Main Results:
- No significant differences were found for respiratory rate and duty cycle between XV and pitot tube.
- XV measured lower tidal volumes and flow rates than the pitot tube, particularly with bilevel-assisted breathing.
- A mixed-model adjustment improved agreement for XV-derived tidal volume and flow rate under higher volume conditions.
Conclusions:
- XV measures of ventilation correlate highly with conventional parameters.
- XV has the potential to provide regional ventilation distribution data beyond conventional pulmonary function tests.
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