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Updated: Jul 17, 2025

Genetic Modification and Recombination of Salivary Gland Organ Cultures
Published on: January 28, 2013
Heterotopia of salivary gland tissue in the pancreas
Sandrina Martens1,2, Katarina Coolens1, Catharina Olsen3,4,5
1Laboratory of Medical and Molecular Oncology, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Abstract:
Heterotopia of the salivary gland occurs mainly in the head and neck region of the human body, rarely in regions such as the rectum, but has never been demonstrated in the pancreas. Within a screening effort of pancreatic samples for detecting ΔNp63 expression, we discovered two pancreatic samples from a 35-year-old male showing salivary gland heterotopia. Immunohistochemical stainings were done for markers of healthy and neoplastic salivary glands and showed expression of calponin, CD142 and KRT14 but not of S100p, GFAP or CD117. A PAS-staining and Alcian Blue staining showed the presence of acid mucins. These staining patterns were consistent with non-neoplastic submandibular gland tissue comprised of abundant seromucous glands, basal cells and myoepithelial cells, all features typically absent in the pancreas. Also, no pancreatic islets of Langerhans were detected. We show for the first time that salivary gland heterotopia can occur at the location of the pancreas.
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