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GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease

Naglaa Makram Farag1, Mahmoud Mousa2, Eman Elsayed2

  • 1Clinical Pathology, Minia University, Minia, Egypt. ahmedmohamedmostafa1971@yahoo.com.

Italian Journal of Pediatrics
|August 30, 2023
PubMed

Insights

Growth differentiation factor-15 (GDF-15) and hepcidin show potential as biomarkers for diagnosing anemia in Egyptian patients with chronic kidney disease (CKD). These markers can help predict anemia, especially when linked to inflammation in CKD.

Area of Science:

  • Nephrology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Anemia is a frequent complication in chronic kidney disease (CKD) patients, worsening their prognosis.
  • The utility of growth differentiation factor-15 (GDF-15) and hepcidin as anemia biomarkers in non-dialysis Egyptian CKD patients remains unclear.

Purpose of the Study:

  • To evaluate the diagnostic validity of GDF-15 and hepcidin for anemia in non-dialysis Egyptian CKD patients.
  • To assess the predictive value of these biomarkers in identifying anemia within this population.

Main Methods:

  • An analytical cross-sectional study involved 60 non-dialysis CKD patients and 28 healthy controls.
  • Serum levels of GDF-15 and hepcidin were measured. Predictive logistic regression and receiver operator characteristic (ROC) analyses were performed.

Main Results:

  • Both hepcidin and GDF-15 levels were significantly higher in CKD patients compared to controls (p < 0.0001).
  • The predictive values for diagnosing anemia using hepcidin and GDF-15 were 72.0% and 70.0%, respectively.
  • GDF-15 showed significant correlations with hemoglobin, ferritin, iron, and C-reactive protein (CRP).

Conclusions:

  • Hepcidin and GDF-15 are potential biomarkers for predicting anemia in Egyptian CKD patients, particularly when associated with inflammation.
  • These markers may aid in the early diagnosis and management of anemia in this vulnerable patient group.
Abstract

Keywords:
AnaemiaChronic kidney diseaseGDF-15Hepcidin

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